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Recent research on creative person has been enriched with a new perspective that brings together the study of brain functioning with the analysis of creative mind and creative behaviour. This chapter attempts to contribute to this effort, by reviewing the literature on brain activity and creativity, within the theoretical framework offered by the multivariate approach. According to this approach the multidimensional creative process is conceptualized as the interaction between person-centred factors, such as cognitive abilities, motivational drives, and personality traits, and contextual influences derived from the environment. Using this approach as a unifying theoretical framework, a coherent picture of the neurological phenomenology of creativity is provided. The viewpoint presented in this chapter should motivate investigators to reflect on the creative brain using wide theoretical lenses such as the one offered by the multivariate approach.